3ARN

Human dUTPase in complex with novel uracil derivative

Summary for 3ARN

Entry DOI	10.2210/pdb3arn/pdb
Related	2HQU 3ARA
Descriptor	Deoxyuridine 5'-triphosphate nucleotidohydrolase, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Nucleus . Isoform 3: Mitochondrion : P33316
Total number of polymer chains	3
Total formula weight	54603.38
Authors	Chong, K.T.,Miyahara, S.,Miyakoshi, H.,Fukuoka, M. (deposition date: 2010-12-03, release date: 2010-12-15, Last modification date: 2024-03-13)
Primary citation	Miyahara, S.,Miyakoshi, H.,Yokogawa, T.,Chong, K.T.,Taguchi, J.,Muto, T.,Endoh, K.,Yano, W.,Wakasa, T.,Ueno, H.,Takao, Y.,Fujioka, A.,Hashimoto, A.,Itou, K.,Yamamura, K.,Nomura, M.,Nagasawa, H.,Shuto, S.,Fukuoka, M. Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors J.Med.Chem., 55:2970-2980, 2012 Cited by PubMed: 22339362 DOI: 10.1021/jm201628y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation