3AQF

Crystal structure of the human CRLR/RAMP2 extracellular complex

Summary for 3AQF

• Entry DOI: 10.2210/pdb3aqf/pdb
• Related: 3AQE
• Descriptor: Receptor activity-modifying protein 2, Calcitonin gene-related peptide type 1 receptor (3 entities in total)
• Functional Keywords: transmembrane, gpcr, adrenomedullin, trafficking, clr, cgrp, endoplasmic reticulum, am-receptor, disease, neovascularization, co-activating receptor for adrenomedullin, adrenomedullin (am), endoplasmic reticulum (er), transport protein-membrane protein complex, transport protein/membrane protein
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: O60895; Cell membrane; Multi-pass membrane protein: Q16602
• Total number of polymer chains: 2
• Total formula weight: 24617.35

Authors

Kusano, S.,Kukimono-Niino, M.,Shirouzu, M.,Shindo, T.,Yokoyama, S. (deposition date: 2010-10-29, release date: 2011-11-02, Last modification date: 2012-07-25)

• Primary citation: Kusano, S.,Kukimoto-Niino, M.,Hino, N.,Ohsawa, N.,Okuda, K.,Sakamoto, K.,Shirouzu, M.,Shindo, T.,Yokoyama, S.; Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding; Protein Sci., 21:199-210, 2012; PubMed: 22102369; DOI: 10.1002/pro.2003

Experimental method

X-RAY DIFFRACTION (2.6 Å)