3AQA

Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1

Summary for 3AQA

Entry DOI	10.2210/pdb3aqa/pdb
Descriptor	Bromodomain-containing protein 2, 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	structural genomics, riken structural genomics/proteomics initiative, rsgi, helical bundle, acetyl-lysine recognition, acetylated histone h4, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P25440
Total number of polymer chains	3
Total formula weight	46323.36
Authors	Umehara, T.,Nakamura, Y.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2010-10-27, release date: 2011-05-18, Last modification date: 2023-11-15)
Primary citation	Ito, T.,Umehara, T.,Sasaki, K.,Nakamura, Y.,Nishino, N.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,Ito, A.,Yoshida, M. Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors Chem.Biol., 18:495-507, 2011 Cited by PubMed: 21513886 DOI: 10.1016/j.chembiol.2011.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation