3AQA
Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Bromodomain-containing protein 2 | polymer | 128 | 15262.6 | 3 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (human) | |
| 2 | A | 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione | non-polymer | 340.5 | 1 | Chemie (BYH) | |||
| 3 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A, B, C: 73 - 194 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 67 | - | expression tag |
| Ser 68 | - | expression tag |
| Ser 69 | - | expression tag |
| Gly 70 | - | expression tag |
| Ser 71 | - | expression tag |
| Ser 72 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45787.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 535.7 | |
| All* | Total formula weight | 46323.4 |
