3APY

Properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8

3APY の概要

• エントリーDOI: 10.2210/pdb3apy/pdb
• 関連するPDBエントリー: 3APT
• 分子名称: Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: tim barrel, oxidoreductase, flavin
• 由来する生物種: Thermus thermophilus
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 283686.56

構造登録者

Yamada, K. (登録日: 2010-10-21, 公開日: 2011-09-14, 最終更新日: 2023-11-01)

主引用文献

Igari, S.,Ohtaki, A.,Yamanaka, Y.,Sato, Y.,Yohda, M.,Odaka, M.,Noguchi, K.,Yamada, K.
Properties and Crystal Structure of Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8.
Plos One, 6:e23716-e23716, 2011

PubMed Abstract: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in homocysteine metabolism. Despite considerable genetic and clinical attention, the reaction mechanism and regulation of this enzyme are not fully understood because of difficult production and poor stability. While recombinant enzymes from thermophilic organisms are often stable and easy to prepare, properties of thermostable MTHFRs have not yet been reported.

PubMed: 21858212
DOI: 10.1371/journal.pone.0023716

実験手法

X-RAY DIFFRACTION (2.8 Å)