3APF

Crystal structure of human PI3K-gamma in complex with CH5039699

Summary for 3APF

Entry DOI	10.2210/pdb3apf/pdb
Related	3APC 3APD
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-[7-(1H-benzimidazol-5-yl)-2-(morpholin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]phenol, ... (4 entities in total)
Functional Keywords	phosphoinositide 3-kinase gamma, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	111054.39
Authors	Nakamura, M.,Fukami, T.A.,Miyazaki, T.,Yoshida, M. (deposition date: 2010-10-14, release date: 2011-04-13, Last modification date: 2023-11-01)
Primary citation	Ohwada, J.,Ebiike, H.,Kawada, H.,Tsukazaki, M.,Nakamura, M.,Miyazaki, T.,Morikami, K.,Yoshinari, K.,Yoshida, M.,Kondoh, O.,Kuramoto, S.,Ogawa, K.,Aoki, Y.,Shimma, N. Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799 Bioorg.Med.Chem.Lett., 21:1767-1772, 2011 Cited by PubMed: 21316229 DOI: 10.1016/j.bmcl.2011.01.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation