3ANW

A protein complex essential initiation of DNA replication

3ANW の概要

• エントリーDOI: 10.2210/pdb3anw/pdb
• 分子名称: Putative uncharacterized protein (3 entities in total)
• 機能のキーワード: sld5 superfamily, dna replication, replication
• 由来する生物種: Thermococcus kodakarensis (Thermococcus kodakaraensis); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41653.08

構造登録者

Oyama, T.,Shirai, T.,Nagasawa, N.,Ishino, Y.,Morikawa, K. (登録日: 2010-09-10, 公開日: 2011-07-27, 最終更新日: 2024-03-13)

主引用文献

Oyama, T.,Ishino, S.,Fujino, S.,Ogino, H.,Shirai, T.,Mayanagi, K.,Saito, M.,Nagasawa, N.,Ishino, Y.,Morikawa, K.
Architectures of archaeal GINS complexes, essential DNA replication initiation factors
Bmc Biol., 9:28-28, 2011

PubMed Abstract: In the early stage of eukaryotic DNA replication, the template DNA is unwound by the MCM helicase, which is activated by forming a complex with the Cdc45 and GINS proteins. The eukaryotic GINS forms a heterotetramer, comprising four types of subunits. On the other hand, the archaeal GINS appears to be either a tetramer formed by two types of subunits in a 2:2 ratio (α2β2) or a homotetramer of a single subunit (α4). Due to the low sequence similarity between the archaeal and eukaryotic GINS subunits, the atomic structures of the archaeal GINS complexes are attracting interest for comparisons of their subunit architectures and organization.

PubMed: 21527023
DOI: 10.1186/1741-7007-9-28

実験手法

X-RAY DIFFRACTION (2.65 Å)