3AID

A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE

3AID の概要

• エントリーDOI: 10.2210/pdb3aid/pdb
• 分子名称: HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM (3 entities in total)
• 機能のキーワード: aspartyl protease, protease, hiv, peptide isostere inhibitor, drug design
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22108.17

構造登録者

Rutenber, E.E.,Stroud, R.M. (登録日: 1997-05-15, 公開日: 1997-09-17, 最終更新日: 2024-05-22)

• 主引用文献: Rutenber, E.E.,McPhee, F.,Kaplan, A.P.,Gallion, S.L.,Hogan Jr., J.C.,Craik, C.S.,Stroud, R.M.; A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.; Bioorg.Med.Chem., 4:1545-1558, 1996; PubMed: 8894111; DOI: 10.1016/0968-0896(96)00147-2

実験手法

X-RAY DIFFRACTION (2.5 Å)