3AH8

Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890

3AH8 の概要

• エントリーDOI: 10.2210/pdb3ah8/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000482
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• 機能のキーワード: heterotrimeric g protein, gtpase, galpha-q, gbeta, ggamma, inhibitor, ym-254890, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Rattus norvegicus (Rat, Mouse); 詳細
• 細胞内の位置: Nucleus : P21279; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 88842.15

構造登録者

Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H. (登録日: 2010-04-20, 公開日: 2010-07-21, 最終更新日: 2023-11-15)

• 主引用文献: Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H.; Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.; Proc.Natl.Acad.Sci.USA, 107:13666-13671, 2010; PubMed: 20639466; DOI: 10.1073/pnas.1003553107

実験手法

X-RAY DIFFRACTION (2.9 Å)