3ABA

Crystal structure of CYP105P1 in complex with filipin I

Summary for 3ABA

Entry DOI	10.2210/pdb3aba/pdb
Related	3ABB 3E5J 3E5K 3E5L
Descriptor	Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,28R)-3-hexyl-4,6,8,10,12,14,16-heptahydroxy-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, ... (5 entities in total)
Functional Keywords	p450, oxidoreductase, heme, monooxygenase, macrolide, filipin, iron, metal-binding, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
Biological source	Streptomyces avermitilis
Total number of polymer chains	1
Total formula weight	45957.00
Authors	Xu, L.H.,Fushinobu, S.,Takamatsu, S.,Wakagi, T.,Ikeda, H.,Shoun, H. (deposition date: 2009-12-04, release date: 2010-04-07, Last modification date: 2023-11-01)
Primary citation	Xu, L.H.,Fushinobu, S.,Takamatsu, S.,Wakagi, T.,Ikeda, H.,Shoun, H. Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis J.Biol.Chem., 285:16844-16853, 2010 Cited by PubMed: 20375018 DOI: 10.1074/jbc.M109.092460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation