3AAU

Bovine beta-trypsin bound to meta-diguanidino schiff base copper (II) chelate

3AAU の概要

• エントリーDOI: 10.2210/pdb3aau/pdb
• 関連するPDBエントリー: 3AAS 3AAV
• 分子名称: Cationic trypsin, N,N'''-{ethane-1,2-diylbis[nitrilo(E)methylylidene(4-hydroxybenzene-3,1-diyl)]}diguanidine, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, coordination metal based inhibitor, hydrolase, calcium, digestion, metal-binding, protease, secreted, serine protease, zymogen
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23810.33

構造登録者

Iyaguchi, D.,Kawano, S.,Toyota, E. (登録日: 2009-11-26, 公開日: 2010-04-07, 最終更新日: 2023-11-01)

• 主引用文献: Iyaguchi, D.,Kawano, S.,Takada, K.,Toyota, E.; Structural basis for the design of novel Schiff base metal chelate inhibitors of trypsin; Bioorg.Med.Chem., 18:2076-2080, 2010; PubMed: 20202854; DOI: 10.1016/j.bmc.2010.02.016

実験手法

X-RAY DIFFRACTION (1.8 Å)