3A7D

Crystal Structures of rat Catechol-O-Methyltransferase complexed with new bi-substrate type inhibitor

Summary for 3A7D

• Entry DOI: 10.2210/pdb3a7d/pdb
• Related: 1JR4 1VID 3A7E
• Descriptor: Catechol O-methyltransferase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, s-adenosyl-l-methionine, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, signal-anchor, transferase, transmembrane
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 1
• Total formula weight: 25661.40

Authors

Tsuji, E. (deposition date: 2009-09-26, release date: 2010-09-15, Last modification date: 2023-11-01)

• Primary citation: Muranaka, H.,Nakatsu, M.,Tsuji, E.,Okazaki, K.; Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 2: Ligand Fishing using Mass Spectrometry by Detection of Ligand-Protein Non-Covalent Complex after Matrix Click Chemistry; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)