3A7D
Crystal Structures of rat Catechol-O-Methyltransferase complexed with new bi-substrate type inhibitor
Summary for 3A7D
Entry DOI | 10.2210/pdb3a7d/pdb |
Related | 1JR4 1VID 3A7E |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, s-adenosyl-l-methionine, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, signal-anchor, transferase, transmembrane |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25661.40 |
Authors | Tsuji, E. (deposition date: 2009-09-26, release date: 2010-09-15, Last modification date: 2023-11-01) |
Primary citation | Muranaka, H.,Nakatsu, M.,Tsuji, E.,Okazaki, K. Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 2: Ligand Fishing using Mass Spectrometry by Detection of Ligand-Protein Non-Covalent Complex after Matrix Click Chemistry To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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