3A4O

Lyn kinase domain

3A4O の概要

• エントリーDOI: 10.2210/pdb3a4o/pdb
• 分子名称: Tyrosine-protein kinase Lyn, STAUROSPORINE (2 entities in total)
• 機能のキーワード: src family, kinase domain, alternative splicing, atp-binding, host-virus interaction, kinase, lipoprotein, myristate, nucleotide-binding, palmitate, phosphoprotein, polymorphism, proto-oncogene, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P07948
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33461.35

構造登録者

Miyano, N.,Kinoshita, T.,Tada, T. (登録日: 2009-07-11, 公開日: 2009-12-08, 最終更新日: 2023-11-01)

主引用文献

Miyano, N.,Kinoshita, T.,Nakai, R.,Kirii, Y.,Yokota, K.,Tada, T.
Structural basis for the inhibitor recognition of human Lyn kinase domain
Bioorg.Med.Chem.Lett., 19:6557-6560, 2009

PubMed Abstract: Human Lyn tyrosine kinase is expressed in hematopoietic tissues and plays crucial roles in the signal transduction of hematopoietic immune system. Its excess activity is involved in several tumors. The crystal structure has revealed that the potent inhibitor staurosporine binds to human Lyn kinase domain at the ATP-binding site. The remarkable structural features of the staurosporine-binding region will offer valuable structural insights for the structure-based design of novel Lyn-selective inhibitors.

PubMed: 19857964
DOI: 10.1016/j.bmcl.2009.10.038

実験手法

X-RAY DIFFRACTION (3 Å)