3A40
Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277B(C23R)
Summary for 3A40
Entry DOI | 10.2210/pdb3a40/pdb |
Related | 1DB1 2HB8 3A3Z 3CS6 |
Descriptor | Vitamin D3 receptor, (1S,2S,3R,5Z,7E,14beta,17alpha,23R)-23-(2-hydroxy-2-methylpropyl)-2-methyl-20,24-epoxy-9,10-secochola-5,7,10-triene-1,3-diol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transcription, structural genomics, spine2, structural proteomics in europe 2, gene regulation, spine-2 |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P11473 |
Total number of polymer chains | 1 |
Total formula weight | 30456.14 |
Authors | Sato, Y.,Antony, P.,Huet, T.,Sigueiro, R.,Rochel, N.,Moras, D.,Structural Proteomics in Europe 2 (SPINE-2) (deposition date: 2009-06-25, release date: 2010-02-02, Last modification date: 2023-11-01) |
Primary citation | Antony, P.,Sigueiro, R.,Huet, T.,Sato, Y.,Ramalanjaona, N.,Rodrigues, L.C.,Mourino, A.,Moras, D.,Rochel, N. Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3 J.Med.Chem., 53:1159-1171, 2010 Cited by PubMed: 20070104DOI: 10.1021/jm9014636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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