3A40
Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277B(C23R)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 23R X 1 |
| Chain | Residue |
| X | TYR143 |
| X | HIS397 |
| X | LEU227 |
| X | SER237 |
| X | ARG274 |
| X | SER275 |
| X | SER278 |
| X | TRP286 |
| X | CYS288 |
| X | HIS305 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 X 428 |
| Chain | Residue |
| X | HOH48 |
| X | HOH106 |
| X | PRO408 |
| X | GLU409 |
| X | CYS410 |
| X | SER411 |
| X | HOH546 |
| X | HOH606 |
| X | HOH662 |
| X | HOH712 |
| X | HOH769 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 X 2 |
| Chain | Residue |
| X | THR280 |
| X | MET281 |
| X | LYS321 |
| X | HOH700 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1, ECO:0007744|PDB:1IE8 |
| Chain | Residue | Details |
| X | TYR143 | |
| X | LEU325 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1 |
| Chain | Residue | Details |
| X | CYS288 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1IE8 |
| Chain | Residue | Details |
| X | GLU329 | |
| X | GLN356 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298 |
| Chain | Residue | Details |
