3A40

Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277B(C23R)

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003677	molecular_function	DNA binding
X	0004879	molecular_function	nuclear receptor activity
X	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 23R X 1

Chain	Residue
X	TYR143
X	HIS397
X	LEU227
X	SER237
X	ARG274
X	SER275
X	SER278
X	TRP286
X	CYS288
X	HIS305

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 X 428

Chain	Residue
X	HOH48
X	HOH106
X	PRO408
X	GLU409
X	CYS410
X	SER411
X	HOH546
X	HOH606
X	HOH662
X	HOH712
X	HOH769

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 X 2

Chain	Residue
X	THR280
X	MET281
X	LYS321
X	HOH700

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"UniProtKB","id":"P13053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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