3A40

Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277B(C23R)

3A40 の概要

• エントリーDOI: 10.2210/pdb3a40/pdb
• 関連するPDBエントリー: 1DB1 2HB8 3A3Z 3CS6
• 分子名称: Vitamin D3 receptor, (1S,2S,3R,5Z,7E,14beta,17alpha,23R)-23-(2-hydroxy-2-methylpropyl)-2-methyl-20,24-epoxy-9,10-secochola-5,7,10-triene-1,3-diol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transcription, structural genomics, spine2, structural proteomics in europe 2, gene regulation, spine-2
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P11473
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30456.14

構造登録者

Sato, Y.,Antony, P.,Huet, T.,Sigueiro, R.,Rochel, N.,Moras, D.,Structural Proteomics in Europe 2 (SPINE-2) (登録日: 2009-06-25, 公開日: 2010-02-02, 最終更新日: 2023-11-01)

• 主引用文献: Antony, P.,Sigueiro, R.,Huet, T.,Sato, Y.,Ramalanjaona, N.,Rodrigues, L.C.,Mourino, A.,Moras, D.,Rochel, N.; Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3; J.Med.Chem., 53:1159-1171, 2010; PubMed: 20070104; DOI: 10.1021/jm9014636

実験手法

X-RAY DIFFRACTION (1.45 Å)