Crystal structure of penicillin binding protein 4 (dacB) from Haemophilus influenzae, complexed with novel beta-lactam (CMV)

Summary for 3A3E

Related3A3D 3A3F 3A3I 3A3J
DescriptorPenicillin-binding protein 4, (2R,4S)-2-[(1R)-1-({(2R)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)amino]-2-phenylacetyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (3 entities in total)
Functional Keywordspenicillin binding protein 4, pbp4, dacb, hydrolase
Biological sourceHaemophilus influenzae
Total number of polymer chains2
Total molecular weight100563.01
Kawai, F.,Roper, D.I.,Park, S.-Y.,Tame, J.R.H. (deposition date: 2009-06-12, release date: 2009-12-22, Last modification date: 2013-11-20)
Primary citation
Kawai, F.,Clarke, T.B.,Roper, D.I.,Han, G.-J.,Hwang, K.Y.,Unzai, S.,Obayashi, E.,Park, S.-Y.,Tame, J.R.H.
Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae
J.Mol.Biol., 396:634-645, 2010
PubMed: 19958776 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.11.055
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27025 2.5% 10.0% 3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28