3A2H

Crystal structure of the rat vitamin D receptor ligand binding domain complexed with TEI-9647 and a synthetic peptide containing the NR2 box of DRIP 205

3A2H の概要

• エントリーDOI: 10.2210/pdb3a2h/pdb
• 関連するPDBエントリー: 3A2I 3A2J
• 分子名称: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1 peptide, (1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one, ... (4 entities in total)
• 機能のキーワード: hormone/growth factor receptor, dna-binding, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, zinc-finger, activator, receptor, hormone receptor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Nucleus: P13053 Q15648
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32052.98

構造登録者

Kakuda, S.,Takimoto-Kamimura, M. (登録日: 2009-05-20, 公開日: 2010-05-26, 最終更新日: 2023-11-01)

• 主引用文献: Kakuda, S.,Ishizuka, S.,Eguchi, H.,Mizwicki, M.T.,Norman, A.W.,Takimoto-Kamimura, M.; Structural basis of the histidine-mediated vitamin D receptor agonistic and antagonistic mechanisms of (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone; Acta Crystallogr.,Sect.D, 66:918-926, 2010; PubMed: 20693691; DOI: 10.1107/S0907444910020810

実験手法

X-RAY DIFFRACTION (2.5 Å)