3A2C

Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2)

3A2C の概要

• エントリーDOI: 10.2210/pdb3a2c/pdb
• 分子名称: MAP kinase-activated protein kinase 2, N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine, SULFATE ION (3 entities in total)
• 機能のキーワード: gly-rich loop formed, aipha-helix, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 459147.09

構造登録者

Fujino, A.,Takimoto-Kamimura, M. (登録日: 2009-05-12, 公開日: 2010-05-12, 最終更新日: 2023-11-01)

• 主引用文献: Fujino, A.,Fukushima, K.,Namiki, N.,Kosugi, T.,Takimoto-Kamimura, M.; Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800; Acta Crystallogr.,Sect.D, 66:80-87, 2010; PubMed: 20057052; DOI: 10.1107/S0907444909046411

実験手法