3A0I

Human glucokinase in complex with a synthetic activator

3A0I の概要

• エントリーDOI: 10.2210/pdb3a0i/pdb
• 関連するPDBエントリー: 1v4s 1v4t 3fr0
• 分子名称: Glucokinase, alpha-D-glucopyranose, 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: glucokinase, diabetes, activator, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51640.60

構造登録者

Kamata, K.,Mitsuya, M. (登録日: 2009-03-19, 公開日: 2009-04-28, 最終更新日: 2023-11-01)

• 主引用文献: Mitsuya, M.,Kamata, K.,Bamba, M.,Watanabe, H.,Sasaki, Y.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Nagata, Y.,Eiki, J.,Nishimura, T.; Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators; Bioorg.Med.Chem.Lett., 19:2718-2721, 2009; PubMed: 19362831; DOI: 10.1016/j.bmcl.2009.03.137

実験手法

X-RAY DIFFRACTION (2.2 Å)