3A0I

Human glucokinase in complex with a synthetic activator

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0000166	molecular_function	nucleotide binding
X	0001678	biological_process	intracellular glucose homeostasis
X	0003824	molecular_function	catalytic activity
X	0004340	molecular_function	glucokinase activity
X	0004396	molecular_function	hexokinase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005536	molecular_function	glucose binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0005829	cellular_component	cytosol
X	0005975	biological_process	carbohydrate metabolic process
X	0006006	biological_process	glucose metabolic process
X	0006007	biological_process	glucose catabolic process
X	0006096	biological_process	glycolytic process
X	0006110	biological_process	regulation of glycolytic process
X	0006739	biological_process	NADP metabolic process
X	0008152	biological_process	metabolic process
X	0008865	molecular_function	fructokinase activity
X	0009749	biological_process	response to glucose
X	0016301	molecular_function	kinase activity
X	0016310	biological_process	phosphorylation
X	0016740	molecular_function	transferase activity
X	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
X	0019158	molecular_function	mannokinase activity
X	0019318	biological_process	hexose metabolic process
X	0019637	biological_process	organophosphate metabolic process
X	0032024	biological_process	positive regulation of insulin secretion
X	0032869	biological_process	cellular response to insulin stimulus
X	0042593	biological_process	glucose homeostasis
X	0043266	biological_process	regulation of potassium ion transport
X	0044320	biological_process	cellular response to leptin stimulus
X	0045721	biological_process	negative regulation of gluconeogenesis
X	0045725	biological_process	positive regulation of glycogen biosynthetic process
X	0046835	biological_process	carbohydrate phosphorylation
X	0050796	biological_process	regulation of insulin secretion
X	0051156	biological_process	glucose 6-phosphate metabolic process
X	0061621	biological_process	canonical glycolysis
X	0070509	biological_process	calcium ion import
X	0141089	molecular_function	glucose sensor activity
X	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvrhedIDkgiLlnWTKgF

Chain	Residue	Details
X	LEU146-PHE171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P19367

Chain	Residue	Details
X	ASP78

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15016359

Chain	Residue	Details
X	SER151
X	THR168
X	ASN204
X	ASN231
X	GLU256
X	GLU290

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8

Chain	Residue	Details
X	THR228
X	GLY295
X	THR332
X	SER411

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 592

Chain	Residue	Details
X	LYS169	proton acceptor, proton donor
X	ASP205	metal ligand, proton acceptor, proton donor

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