3ZPQ
Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19)
Summary for 3ZPQ
Entry DOI | 10.2210/pdb3zpq/pdb |
Related | 3ZPR |
Descriptor | BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ... (6 entities in total) |
Functional Keywords | membrane protein, gpcr, fragment screening, aryl piperazine, structure based drug design |
Biological source | MELEAGRIS GALLOPAVO (TURKEY) |
Total number of polymer chains | 2 |
Total formula weight | 77715.36 |
Authors | Christopher, J.A.,Congreve, M.,Dore, A.S.,Marshall, F.H.,Myszka, D.G.,Brown, J.,Koglin, M.,Tehan, B.,Errey, J.C.,Tate, C.G.,Warne, T. (deposition date: 2013-03-01, release date: 2013-04-03, Last modification date: 2023-12-20) |
Primary citation | Christopher, J.,Brown, J.,Dore, A.,Errey, J.,Koglin, M.,Marshall, F.H.,Myszka, D.,Rich, R.L.,Tate, C.G.,Tehan, B.,Warne, T.,Congreve, M. Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design. J.Med.Chem., 56:3446-, 2013 Cited by PubMed: 23517028DOI: 10.1021/JM400140Q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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