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3ZLQ

BACE2 XAPERONE COMPLEX

Summary for 3ZLQ
Entry DOI10.2210/pdb3zlq/pdb
DescriptorBETA-SECRETASE 2, XA4813, 5-Ethoxy-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide, ... (4 entities in total)
Functional Keywordshydrolase-immune system complex, hydrolase/immune system
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationMembrane; Single-pass type I membrane protein: Q9Y5Z0
Total number of polymer chains4
Total formula weight111216.50
Authors
Kuglstatter, A.,Stihle, M. (deposition date: 2013-02-04, release date: 2013-05-01, Last modification date: 2013-06-05)
Primary citationHilpert, H.,Guba, W.,Woltering, T.J.,Wostl, W.,Pinard, E.,Mauser, H.,Mayweg, A.V.,Rogers-Evans, M.,Humm, R.,Krummenacher, D.,Muser, T.,Schnider, C.,Jacobsen, H.,Ozmen, L.,Bergadano, A.,Banner, D.W.,Hochstrasser, R.,Kuglstatter, A.,David-Pierson, P.,Fischer, H.,Polara, A.,Narquizian, R.
Beta-Secretase (Bace1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer'S Disease.
J.Med.Chem., 56:3980-, 2013
Cited by
PubMed: 23590342
DOI: 10.1021/JM400225M
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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