3WN5

Crystal structure of asymmetrically engineered Fc variant in complex with FcgRIIIa

Summary for 3WN5

Entry DOI	10.2210/pdb3wn5/pdb
Descriptor	Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	receptor complex, fc receptor, antibody, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	159759.31
Authors	Kadono, S.,Mimoto, F.,Katada, H.,Igawa, T.,Kamikawa, T.,Hattori, K. (deposition date: 2013-12-05, release date: 2014-11-19, Last modification date: 2020-07-29)
Primary citation	Mimoto, F.,Kadono, S.,Katada, H.,Igawa, T.,Kamikawa, T.,Hattori, K. Crystal structure of a novel asymmetrically engineered Fc variant with improved affinity for Fc gamma Rs. Mol.Immunol., 58:132-138, 2014 Cited by PubMed: 24334029 DOI: 10.1016/j.molimm.2013.11.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation