3WIX
Crystal structure of Mcl-1 in complex with compound 4
Summary for 3WIX
Entry DOI | 10.2210/pdb3wix/pdb |
Related | 3WIY 3WIZ |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid (3 entities in total) |
Functional Keywords | regulation, apoptosis |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q07820 |
Total number of polymer chains | 4 |
Total formula weight | 74684.68 |
Authors | Sogabe, S.,Igaki, S.,Hayano, Y. (deposition date: 2013-09-26, release date: 2013-11-27, Last modification date: 2023-11-08) |
Primary citation | Tanaka, Y.,Aikawa, K.,Nishida, G.,Homma, M.,Sogabe, S.,Igaki, S.,Hayano, Y.,Sameshima, T.,Miyahisa, I.,Kawamoto, T.,Tawada, M.,Imai, Y.,Inazuka, M.,Cho, N.,Imaeda, Y.,Ishikawa, T. Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J.Med.Chem., 56:9635-9645, 2013 Cited by PubMed: 24215352DOI: 10.1021/jm401170c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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