3WD5
Crystal structure of TNFalpha in complex with Adalimumab Fab fragment
Summary for 3WD5
Entry DOI | 10.2210/pdb3wd5/pdb |
Related | 4G3Y |
Descriptor | Tumor necrosis factor, Adalimumab Light Chain, Adalimumab Heavy Chain, ... (4 entities in total) |
Functional Keywords | antibody binding epitope, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375 |
Total number of polymer chains | 3 |
Total formula weight | 63935.43 |
Authors | Hu, S.,Liang, S.Y.,Guo, Y.J.,Lou, Z.Y. (deposition date: 2013-06-06, release date: 2013-08-14, Last modification date: 2015-07-01) |
Primary citation | Hu, S.,Liang, S.Y.,Guo, H.,Zhang, D.,Li, H.,Wang, X.,Yang, W.,Qian, W.,Hou, S.,Wang, H.,Guo, Y.J.,Lou, Z.Y. Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view J.Biol.Chem., 288:27059-27067, 2013 Cited by PubMed: 23943614DOI: 10.1074/jbc.M113.491530 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.101 Å) |
Structure validation
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