3VSO

Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21

Summary for 3VSO

Entry DOI	10.2210/pdb3vso/pdb
Related	3VSP 3an3
Descriptor	Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid (3 entities in total)
Functional Keywords	mainly alpha, nuclear receptor, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65570.90
Authors	Oyama, T.,Waku, T.,Ohashi, M.,Morikawa, K.,Miyachi, H. (deposition date: 2012-04-30, release date: 2013-05-01, Last modification date: 2023-11-08)
Primary citation	Ohashi, M.,Oyama, T.,Putranto, E.W.,Waku, T.,Nobusada, H.,Kataoka, K.,Matsuno, K.,Yashiro, M.,Morikawa, K.,Huh, N.H.,Miyachi, H. Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility Bioorg.Med.Chem., 21:2319-2332, 2013 Cited by PubMed: 23490155 DOI: 10.1016/j.bmc.2013.02.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation