3VSO
Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21
Summary for 3VSO
Entry DOI | 10.2210/pdb3vso/pdb |
Related | 3an3 3VSP |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid (3 entities in total) |
Functional Keywords | mainly alpha, nuclear receptor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65570.90 |
Authors | Oyama, T.,Waku, T.,Ohashi, M.,Morikawa, K.,Miyachi, H. (deposition date: 2012-04-30, release date: 2013-05-01, Last modification date: 2023-11-08) |
Primary citation | Ohashi, M.,Oyama, T.,Putranto, E.W.,Waku, T.,Nobusada, H.,Kataoka, K.,Matsuno, K.,Yashiro, M.,Morikawa, K.,Huh, N.H.,Miyachi, H. Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility Bioorg.Med.Chem., 21:2319-2332, 2013 Cited by PubMed: 23490155DOI: 10.1016/j.bmc.2013.02.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report