3VJH
Human PPAR GAMMA ligand binding domain in complex with JKPL35
Summary for 3VJH
Entry DOI | 10.2210/pdb3vjh/pdb |
Related | 3VJI |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-[4-methoxy-3-({[4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]pentanoic acid (3 entities in total) |
Functional Keywords | transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65484.73 |
Authors | Tomioka, D.,Kuwabara, N.,Hashimoto, H.,Sato, M.,Shimizu, T. (deposition date: 2011-10-20, release date: 2012-08-29, Last modification date: 2023-11-08) |
Primary citation | Kuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H. Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype. J.Med.Chem., 55:893-902, 2012 Cited by PubMed: 22185225DOI: 10.1021/jm2014293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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