3VF8
Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416
Summary for 3VF8
Entry DOI | 10.2210/pdb3vf8/pdb |
Related | 3V5J 3V5L 3V8W 3VF9 |
Descriptor | Tyrosine-protein kinase SYK, 3-[5-(5-ethoxy-6-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethylurea (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 35241.35 |
Authors | McLean, L.R.,Zhang, Y. (deposition date: 2012-01-09, release date: 2012-05-02, Last modification date: 2024-02-28) |
Primary citation | McLean, L.R.,Zhang, Y.,Zaidi, N.,Bi, X.,Wang, R.,Dharanipragada, R.,Jurcak, J.G.,Gillespy, T.A.,Zhao, Z.,Musick, K.Y.,Choi, Y.M.,Barrague, M.,Peppard, J.,Smicker, M.,Duguid, M.,Parkar, A.,Fordham, J.,Kominos, D. X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22:3296-3300, 2012 Cited by PubMed: 22464456DOI: 10.1016/j.bmcl.2012.03.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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