3UXP
Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP
Summary for 3UXP
Entry DOI | 10.2210/pdb3uxp/pdb |
Related | 3UXN 3UXO |
Descriptor | DNA polymerase beta, DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', ... (6 entities in total) |
Functional Keywords | pol beta, repair polymerase, ber, transferase, lyase-dna complex, lyase/dna |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Nucleus: P06766 |
Total number of polymer chains | 6 |
Total formula weight | 87623.26 |
Authors | Gridley, C.L.,Jaeger, J. (deposition date: 2011-12-05, release date: 2012-12-05, Last modification date: 2024-02-28) |
Primary citation | Gridley, C.L.,Rangarajan, S.,Firbank, S.,Dalal, S.,Sweasy, J.B.,Jaeger, J. Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry, 52:4422-4432, 2013 Cited by PubMed: 23651085DOI: 10.1021/bi301368f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.723 Å) |
Structure validation
Download full validation report