3UVV
Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid
Summary for 3UVV
Entry DOI | 10.2210/pdb3uvv/pdb |
Descriptor | Thyroid hormone receptor alpha, Retinoic acid receptor RXR-alpha, 3,5,3'TRIIODOTHYRONINE, ... (5 entities in total) |
Functional Keywords | tr-rxr heterodimer, allostery, alpha helical sandwich, transactivation, hormone receptor-hormone receptor complex, hormone receptor/hormone receptor |
Biological source | Gallus gallus (bantam,chickens) More |
Cellular location | Nucleus: P04625 P19793 |
Total number of polymer chains | 2 |
Total formula weight | 58388.98 |
Authors | Fernandez, E.J.,Putcha, B.-D.K.,Wright, E.,Brunzelle, J.S. (deposition date: 2011-11-30, release date: 2012-04-18, Last modification date: 2023-11-15) |
Primary citation | Putcha, B.D.,Wright, E.,Brunzelle, J.S.,Fernandez, E.J. Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers. Proc.Natl.Acad.Sci.USA, 109:6084-6087, 2012 Cited by PubMed: 22474364DOI: 10.1073/pnas.1119852109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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