3UVV

Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Thyroid hormone receptor alpha	polymer	265	30090.8	1	UniProt (P04625) Pfam (PF00104) In PDB	Gallus gallus (bantam chickens)	Nuclear receptor subfamily 1 group A member 1
2	B	Retinoic acid receptor RXR-alpha	polymer	244	27346.8	1	UniProt (P19793) Pfam (PF00104) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
3	A	3,5,3'TRIIODOTHYRONINE	non-polymer		651.0	1	Chemie (T3)
4	B	(9cis)-retinoic acid	non-polymer		300.4	1	Chemie (9CR)
5		water	water		18.0	19	Chemie (HOH)

Sequence modifications

A: 148 - 408 (UniProt: P04625)

PDB	External Database	Details
Gly 144	-	expression tag
Ser 145	-	expression tag
His 146	-	expression tag
Glu 147	-	expression tag

B: 225 - 462 (UniProt: P19793)

PDB	External Database	Details
Met 221	-	expression tag
Lys 222	-	expression tag
Lys 223	-	expression tag
Gly 224	-	expression tag
Met 463	-	expression tag
Thr 464	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57437.6
Non-Polymers*	Number of molecules	2
	Total formula weight	951.4
All*	Total formula weight	58389.0

*Water molecules are not included.