3UVV
Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thyroid hormone receptor alpha | polymer | 265 | 30090.8 | 1 | UniProt (P04625) Pfam (PF00104) | Gallus gallus (bantam chickens) | Nuclear receptor subfamily 1 group A member 1 |
| 2 | B (B) | Retinoic acid receptor RXR-alpha | polymer | 244 | 27346.8 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha |
| 3 | C (A) | 3,5,3'TRIIODOTHYRONINE | non-polymer | 651.0 | 1 | Chemie (T3) | |||
| 4 | D (B) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 148 - 408 (UniProt: P04625)
B: 225 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 144 | - | expression tag |
| Ser 145 | - | expression tag |
| His 146 | - | expression tag |
| Glu 147 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 221 | - | expression tag |
| Lys 222 | - | expression tag |
| Lys 223 | - | expression tag |
| Gly 224 | - | expression tag |
| Met 463 | - | expression tag |
| Thr 464 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57437.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 951.4 | |
| All* | Total formula weight | 58389.0 |
