3U7U
Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Summary for 3U7U
Entry DOI | 10.2210/pdb3u7u/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-4, Neuregulin 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | signaling protein, transferase-transferase regulator complex, glycosylation, transferase/transferase regulator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 455341.19 |
Authors | Liu, P.,Cleveland IV, T.E.,Bouyain, S.,Longo, P.A.,Leahy, D.J. (deposition date: 2011-10-14, release date: 2012-08-29, Last modification date: 2023-09-13) |
Primary citation | Liu, P.,Cleveland, T.E.,Bouyain, S.,Byrne, P.O.,Longo, P.A.,Leahy, D.J. A single ligand is sufficient to activate EGFR dimers. Proc.Natl.Acad.Sci.USA, 109:10861-10866, 2012 Cited by PubMed: 22699492DOI: 10.1073/pnas.1201114109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.03 Å) |
Structure validation
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