3U7U
Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Receptor tyrosine-protein kinase erbB-4 | polymer | 615 | 68735.5 | 6 | UniProt (Q15303) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB | Homo sapiens (human) | Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4 |
| 2 | G, H, I, J, K... | Neuregulin 1 | polymer | 55 | 6196.1 | 6 | UniProt (Q96IB3) Pfam (PF00008) UniProt (by SIFTS) (Q02297) In PDB | Homo sapiens (human) | |
| 3 | D, E, F, A, B... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 26 | Chemie (NAG) | |||
| 4 | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 615 (UniProt: Q15303)
| PDB | External Database | Details |
|---|---|---|
| Asp 524 | Gly 549 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 449589.8 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 5751.4 | |
| All* | Total formula weight | 455341.2 |
