3TGK

TRYPSINOGEN MUTANT D194N AND DELETION OF ILE 16-VAL 17 COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)

Summary for 3TGK

• Entry DOI: 10.2210/pdb3tgk/pdb
• Related: 1F5R 1F7Z 1FY8
• Descriptor: TRYPSIN II, ANIONIC, PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: serine protease, complex (serine protease-inhibitor), hydrolase- hydrolase inhibitor complex, hydrolase/ hydrolase inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Secreted, extracellular space: P00763; Secreted: P00974
• Total number of polymer chains: 2
• Total formula weight: 32400.45

Authors

Pasternak, A.,White, A.,Jeffery, C.J.,Medina, N.,Cahoon, M.,Ringe, D.,Hedstrom, L. (deposition date: 1998-07-19, release date: 2001-07-04, Last modification date: 2023-12-27)

• Primary citation: Pasternak, A.,White, A.,Jeffery, C.J.,Medina, N.,Cahoon, M.,Ringe, D.,Hedstrom, L.; The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.; Protein Sci., 10:1331-1342, 2001; PubMed: 11420435; DOI: 10.1110/ps.44101

Experimental method

X-RAY DIFFRACTION (1.7 Å)