3TFB

Transthyretin natural mutant A25T

Summary for 3TFB

• Entry DOI: 10.2210/pdb3tfb/pdb
• Descriptor: Transthyretin (2 entities in total)
• Functional Keywords: transthyretin, immunoglobulin-like, transport protein, extracellular, hormone-binding protein, hormone binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 25466.49

Authors

Azevedo, E.P.C.,Pereira, H.M.,Garratt, R.C.,Kelly, J.W.,Foguel, D.,Palhano, F.L. (deposition date: 2011-08-15, release date: 2011-12-07, Last modification date: 2023-09-13)

• Primary citation: Azevedo, E.P.,Pereira, H.M.,Garratt, R.C.,Kelly, J.W.,Foguel, D.,Palhano, F.L.; Dissecting the Structure, Thermodynamic Stability, and Aggregation Properties of the A25T Transthyretin (A25T-TTR) Variant Involved in Leptomeningeal Amyloidosis: Identifying Protein Partners That Co-Aggregate during A25T-TTR Fibrillogenesis in Cerebrospinal Fluid.; Biochemistry, 50:11070-11083, 2011; PubMed: 22091638; DOI: 10.1021/bi201365r

Experimental method

X-RAY DIFFRACTION (2.033 Å)