3T6P
IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization
Summary for 3T6P
Entry DOI | 10.2210/pdb3t6p/pdb |
Descriptor | Baculoviral IAP repeat-containing protein 2, ZINC ION (3 entities in total) |
Functional Keywords | ring, bir, card, uba, apoptosis, e3, ubiquitin ligase, smac/diablo, ubiquitin, caspase, iap family, smac mimetic |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (Potential): Q13490 |
Total number of polymer chains | 1 |
Total formula weight | 39473.38 |
Authors | Dueber, E.C.,Schoeffler, A.J.,Lingel, A.,Elliott, M.,Fedorova, A.V.,Giannetti, A.M.,Zobel, K.,Maurer, B.,Varfolomeev, E.,Wu, P.,Wallweber, H.,Hymowitz, S.,Deshayes, K.,Vucic, D.,Fairbrother, W.J. (deposition date: 2011-07-28, release date: 2011-11-02, Last modification date: 2024-02-28) |
Primary citation | Dueber, E.C.,Schoeffler, A.J.,Lingel, A.,Elliott, J.M.,Fedorova, A.V.,Giannetti, A.M.,Zobel, K.,Maurer, B.,Varfolomeev, E.,Wu, P.,Wallweber, H.J.,Hymowitz, S.G.,Deshayes, K.,Vucic, D.,Fairbrother, W.J. Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334:376-380, 2011 Cited by PubMed: 22021857DOI: 10.1126/science.1207862 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.897 Å) |
Structure validation
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