3T6P
IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Baculoviral IAP repeat-containing protein 2 | polymer | 345 | 39277.2 | 1 | UniProt (Q13490) Pfam (PF00653) Pfam (PF21290) Pfam (PF00619) Pfam (PF13920) | Homo sapiens (human) | C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, IAP-2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2 |
| 2 | B, C, D (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E (A) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 265 - 618 (UniProt: Q13490)
| PDB | External Database | Details |
|---|---|---|
| Gly 264 | - | expression tag |
| Ser 308 | Cys 308 | conflict |
| - | Ser 363 | deletion |
| - | Asp 364 | deletion |
| - | Thr 365 | deletion |
| - | Thr 366 | deletion |
| - | Gly 367 | deletion |
| - | Glu 368 | deletion |
| - | Glu 369 | deletion |
| - | Asn 370 | deletion |
| - | Ala 371 | deletion |
| - | Asp 372 | deletion |
| Tyr 378 | Phe 378 | engineered mutation |
| Ser 527 | Cys 527 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39277.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 39473.4 |
