3T06

Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA

Summary for 3T06

Entry DOI	10.2210/pdb3t06/pdb
Descriptor	Rho guanine nucleotide exchange factor 11, Transforming protein RhoA (2 entities in total)
Functional Keywords	dh-ph rhoa complex, pdzrhogef, guanine nucleotide exchange factor, rhoa, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm : O15085 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains	4
Total formula weight	137247.51
Authors	Bielnicki, J.A.,Derewenda, U.,Derewenda, Z.S. (deposition date: 2011-07-19, release date: 2011-08-03, Last modification date: 2023-09-13)
Primary citation	Bielnicki, J.A.,Shkumatov, A.V.,Derewenda, U.,Somlyo, A.V.,Svergun, D.I.,Derewenda, Z.S. Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. J.Biol.Chem., 286:35163-35175, 2011 Cited by PubMed: 21816819 DOI: 10.1074/jbc.M111.270918 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation