3T06

Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Rho guanine nucleotide exchange factor 11	polymer	418	48462.7	2	UniProt (O15085) Pfam (PF00621) Pfam (PF17838) In PDB	Homo sapiens (human)	PDZ-RhoGEF
2	B, F	Transforming protein RhoA	polymer	178	20161.0	2	UniProt (P61586) Pfam (PF00071) In PDB	Homo sapiens (human)	Rho cDNA clone 12, h12

Sequence modifications

A, E: 672 - 1081 (UniProt: O15085)

PDB	External Database	Details
His 1082	-	expression tag
His 1083	-	expression tag
His 1084	-	expression tag
His 1085	-	expression tag
His 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag

B, F: 3 - 180 (UniProt: P61586)

PDB	External Database	Details
Asn 25	Phe 25	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137247.5
All*	Total formula weight	137247.5

*Water molecules are not included.