3SME

Structure of PTP1B inactivated by H2O2/bicarbonate

Summary for 3SME

Entry DOI	10.2210/pdb3sme/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, MAGNESIUM ION (3 entities in total)
Functional Keywords	hydrolase, sulfenyl amide bond between cys 215 and ser 216
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	34940.07
Authors	Tanner, J.J.,Singh, H. (deposition date: 2011-06-27, release date: 2011-10-19, Last modification date: 2023-09-13)
Primary citation	Zhou, H.,Singh, H.,Parsons, Z.D.,Lewis, S.M.,Bhattacharya, S.,Seiner, D.R.,Labutti, J.N.,Reilly, T.J.,Tanner, J.J.,Gates, K.S. The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133:15803-15805, 2011 Cited by PubMed: 21913686 DOI: 10.1021/ja2077137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation