3SI7

The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant

Summary for 3SI7

Entry DOI	10.2210/pdb3si7/pdb
Descriptor	Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	cystic fibrosis, atp-binding domain, hydrolase
Biological source	Mus musculus (mouse)
Cellular location	Early endosome membrane; Multi-pass membrane protein (By similarity): P26361
Total number of polymer chains	4
Total formula weight	130441.08
Authors	Brautigam, C.A.,Caspa, E.,Thomas, P.J. (deposition date: 2011-06-17, release date: 2012-02-01, Last modification date: 2024-02-28)
Primary citation	Mendoza, J.L.,Schmidt, A.,Li, Q.,Nuvaga, E.,Barrett, T.,Bridges, R.J.,Feranchak, A.P.,Brautigam, C.A.,Thomas, P.J. Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences Cell(Cambridge,Mass.), 148:164-174, 2012 Cited by PubMed: 22265409 DOI: 10.1016/j.cell.2011.11.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation