3SAZ
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor
Summary for 3SAZ
Entry DOI | 10.2210/pdb3saz/pdb |
Related | 1N8I 1N8W 2GQ3 3S9I 3S9Z 3SAD 3SB0 |
Descriptor | Malate synthase G, 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | inhibitor complex, structural genomics, mycobacterium tuberculosis structural proteomics project, xmtb, malate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 80800.71 |
Authors | Krieger, I.V.,Sun, Q.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (deposition date: 2011-06-03, release date: 2012-11-07, Last modification date: 2023-09-13) |
Primary citation | Krieger, I.V.,Freundlich, J.S.,Gawandi, V.B.,Roberts, J.P.,Gawandi, V.B.,Sun, Q.,Owen, J.L.,Fraile, M.T.,Huss, S.I.,Lavandera, J.L.,Ioerger, T.R.,Sacchettini, J.C. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19:1556-1567, 2012 Cited by PubMed: 23261599DOI: 10.1016/j.chembiol.2012.09.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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