3S91

Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1

Summary for 3S91

• Entry DOI: 10.2210/pdb3s91/pdb
• Related: 3S92
• Descriptor: Bromodomain-containing protein 3, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, ISOPROPYL ALCOHOL, ... (4 entities in total)
• Functional Keywords: brd3, bromodomain containing protein 3, orfx, ring3 like gene, ring3l, jq1, structural genomics, structural genomics consortium, sgc, unknown function
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (Potential): Q15059
• Total number of polymer chains: 1
• Total formula weight: 15104.93

Authors

Filippakopoulos, P.,Picaud, S.,Qi, J.,Keates, T.,Felletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bradner, J.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-05-31, release date: 2011-06-29, Last modification date: 2023-09-13)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Qi, J.,Keates, T.,Felletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bradner, J.E.,Knapp, S.; Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1; To be Published,

Experimental method

X-RAY DIFFRACTION (2.06 Å)