3S7A

Human dihydrofolate reductase binary complex with PT684

Summary for 3S7A

• Entry DOI: 10.2210/pdb3s7a/pdb
• Descriptor: Dihydrofolate reductase, SULFATE ION, 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, ... (4 entities in total)
• Functional Keywords: single polypeptide chain, reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22299.33

Authors

Cody, V.,Pace, J.,Nowak, J. (deposition date: 2011-05-26, release date: 2011-10-05, Last modification date: 2023-09-13)

• Primary citation: Cody, V.,Pace, J.,Nowak, J.; Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode.; Acta Crystallogr.,Sect.D, 67:875-880, 2011; PubMed: 21931219; DOI: 10.1107/S0907444911030071

Experimental method

X-RAY DIFFRACTION (1.8 Å)