3S41
Glucokinase in complex with activator and glucose
Summary for 3S41
Entry DOI | 10.2210/pdb3s41/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, SODIUM ION, ... (5 entities in total) |
Functional Keywords | diabetes mellitus, disease mutation, glycolysis, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53574.71 |
Authors | |
Primary citation | Pfefferkorn, J.A.,Guzman-Perez, A.,Oates, P.J.,Litchfield, J.,Aspnes, G.,Basak, A.,Benbow, J.,Berliner, M.A.,Bian, J.,Choi, C.,Freeman-Cook, K.,Corbett, J.W.,Didiuk, M.,Dunetz, J.R.,Filipski, K.J.,Hungerford, W.M.,Jones, C.S.,Karki, K.,Ling, A.,Li, J.-C.,Patel, L.,Perreault, C.,Risley, H.,Saenz, J.,Song, W.,Tu, M.,Aiello, R.,Atkinson, K.,Barucci, N.,Beebe, D.,Bourassa, P.,Bourbounais, F.,Brodeur, A.M.,Burbey, R.,Chen, J.,D'Aquila, T.,Derksen, D.R.,Haddish-Berhane, N.,Huang, C.,Landro, J.,Lapworth, A.L.,MacDougall, M.,Perregaux, D.,Pettersen, J.,Robertson, A.,Tan, B.,Treadway, J.L.,Liu, S.,Qiu, X.,Knafels, J.,Ammirati, M.,Song, X.,DaSilva-Jardine, P.,Liras, S.,Sweet, L.,Rolph, T.P. Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus MEDCHEMCOMM, 2:828-839, 2011 Cited by DOI: 10.1039/C1MD00116GPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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