3S41

Glucokinase in complex with activator and glucose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glucokinase	polymer	469	52939.1	1	UniProt (P35557) Pfam (PF00349) Pfam (PF03727)	Homo sapiens (human)	Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
2	B (A)	alpha-D-glucopyranose	non-polymer		180.2	1	Chemie (GLC)
3	C (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	D (A)	N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide	non-polymer		432.4	1	Chemie (S41)
5	E (A)	water	water		18.0	181	Chemie (HOH)

Sequence modifications

A: 12 - 465 (UniProt: P35557)

PDB	External Database	Details
Met -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Glu 4	-	expression tag
Asn 5	-	expression tag
Leu 6	-	expression tag
Tyr 7	-	expression tag
Phe 8	-	expression tag
Gln 9	-	expression tag
Gly 10	-	expression tag
Met 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52939.1
Non-Polymers*	Number of molecules	3
	Total formula weight	635.6
All*	Total formula weight	53574.7

*Water molecules are not included.