3S3I
p38 kinase crystal structure in complex with small molecule inhibitor
Summary for 3S3I
Entry DOI | 10.2210/pdb3s3i/pdb |
Descriptor | Mitogen-activated protein kinase 14, 3-(3-tert-butyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-4-methylbenzamide (3 entities in total) |
Functional Keywords | p38 map kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 40383.25 |
Authors | Segarra, V.,Aiguade, J.,Roca, R.,Fisher, M.,Lamers, M. (deposition date: 2011-05-18, release date: 2012-04-04, Last modification date: 2023-09-13) |
Primary citation | Aiguade, J.,Balague, C.,Carranco, I.,Caturla, F.,Dominguez, M.,Eastwood, P.,Esteve, C.,Gonzalez, J.,Lumeras, W.,Orellana, A.,Preciado, S.,Roca, R.,Vidal, L.,Vidal, B. Novel triazolopyridylbenzamides as potent and selective p38 alpha inhibitors. Bioorg.Med.Chem.Lett., 22:3431-3436, 2012 Cited by PubMed: 22521646DOI: 10.1016/j.bmcl.2012.03.099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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