3S2V
Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution
Summary for 3S2V
Entry DOI | 10.2210/pdb3s2v/pdb |
Related | 2F34 |
Descriptor | Glutamate receptor, ionotropic kainate 1, (S)-1-(2'-AMINO-2'-CARBOXYETHYL)-3-[(2-CARBOXYTHIEN-3-YL)METHYL]THIENO[3,4-D]PYRIMIDIN-2,4-DIONE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | antagonist, ionotropic glutamate receptor, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P22756 |
Total number of polymer chains | 2 |
Total formula weight | 59515.56 |
Authors | Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2011-05-17, release date: 2011-06-22, Last modification date: 2023-09-13) |
Primary citation | Venskutonyte, R.,Butini, S.,Coccone, S.S.,Gemma, S.,Brindisi, M.,Kumar, V.,Guarino, E.,Maramai, S.,Valenti, S.,Amir, A.,Valades, E.A.,Frydenvang, K.,Kastrup, J.S.,Novellino, E.,Campiani, G.,Pickering, D.S. Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. J.Med.Chem., 54:4793-4805, 2011 Cited by PubMed: 21619066DOI: 10.1021/jm2004078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report