3S2V
Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 3HU A 258 |
| Chain | Residue |
| A | TYR16 |
| A | GLU190 |
| A | SER193 |
| A | TYR216 |
| A | HOH263 |
| A | HOH284 |
| A | HOH330 |
| A | HOH416 |
| A | HOH434 |
| A | TYR61 |
| A | PRO88 |
| A | LEU89 |
| A | THR90 |
| A | ARG95 |
| A | VAL137 |
| A | SER141 |
| A | THR142 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 259 |
| Chain | Residue |
| A | ASP212 |
| A | SER213 |
| A | HOH277 |
| A | HOH317 |
| A | HOH369 |
| A | HOH406 |
| A | HOH414 |
| A | HOH421 |
| A | HOH425 |
| B | GLN238 |
| B | HIS244 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 260 |
| Chain | Residue |
| A | ARG31 |
| A | LEU55 |
| A | LYS171 |
| A | HOH389 |
| A | HOH433 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3HU B 258 |
| Chain | Residue |
| B | TYR16 |
| B | TYR61 |
| B | PRO88 |
| B | LEU89 |
| B | THR90 |
| B | ARG95 |
| B | SER141 |
| B | THR142 |
| B | GLU190 |
| B | SER193 |
| B | TYR216 |
| B | HOH264 |
| B | HOH275 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 259 |
| Chain | Residue |
| A | HIS244 |
| B | TYR154 |
| B | ASP212 |
| B | SER213 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 260 |
| Chain | Residue |
| B | ARG115 |
| B | ASN203 |
| B | HOH376 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 261 |
| Chain | Residue |
| B | ASN172 |
| B | SER173 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 262 |
| Chain | Residue |
| A | ILE7 |
| A | HIS80 |
| A | ARG81 |
| A | ALA82 |
| A | ASP83 |
| B | PRO25 |
| B | LEU26 |
| B | HOH391 |
| B | HOH392 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
